Observing adaptive evolution is difficult. In the fossil record, phenotypic evolution happens much more slowly than in artificial selection experiments or in experimental evolution. Yet measures of selection on phenotypic traits, with high heritabilities, suggest that phenotypic evolution should also be rapid in the wild, and this discrepancy often remains even after accounting for correlations between different traits (i.e. making predictions using the multivariate version of the breeder's equation). Are fitness correlations with quantitative traits adequate measures of selection in the (...) wild? We should instead view fitnesses as average properties of genotypes, while acknowledging that they can be environment‐dependent. Populations will tend to remain at fitness equilibria, once these are attained, and phenotypes will then be stable. Thus, studying the causes of adaptive change at a genotypic rather than phenotypic level may reveal that, typically, it is occurring too slowly to be easily observed. (shrink)

The Alu sequence is a SINE (Short INterspersed Element) that is abundant in the human genome. A new analysis(1) reveals an unexpected conservation of some bases in the DNA sequence of the element. The bases involved include those forming an RNA polymerase III promoter. An unresolved question is whether this conservation results from selection for transposability. This, in turn, is related to the larger question of the evolutionary relationship between members of the Alu sequence family.

BackgroundECMO is a particularly scarce resource during the COVID-19 pandemic. Its allocation involves ethical considerations that may be different to usual times. There is limited pre-pandemic literature on the ethical factors that ECMO physicians consider during ECMO allocation. During the pandemic, there has been relatively little professional guidance specifically relating to ethics and ECMO allocation; although there has been active ethical debate about allocation of other critical care resources. We report the results of a small international exploratory survey of ECMO (...) clinicians’ views on different patient factors in ECMO decision-making prior to and during the COVID-19 pandemic. We then outline current ethical decision procedures and recommendations for rationing life-sustaining treatment during the COVID-19 pandemic, and examine the extent to which current guidelines for ECMO allocation (and reported practice) adhere to these ethical guidelines and recommendations.MethodsAn online survey was performed with responses recorded between mid May and mid August 2020. Participants (n = 48) were sourced from the ECMOCard study group—an international group of experts (n = 120) taking part in a prospective international study of ECMO and intensive care for patients during the COVID-19 pandemic. The survey compared the extent to which certain ethical factors involved in ECMO resource allocation were considered prior to and during the pandemic.ResultsWhen initiating ECMO during the pandemic, compared to usual times, participants reported giving more ethical weight to the benefit of ECMO to other patients not yet admitted as opposed to those already receiving ECMO, (p < 0.001). If a full unit were referred a good candidate for ECMO, participants were more likely during the pandemic to consider discontinuing ECMO from a current patient with low chance of survival (53% during pandemic vs. 33% prior p = 0.002). If the clinical team recommends that ECMO should cease, but family do not agree, the majority of participants indicated that they would continue treatment, both in usual circumstances (67%) and during the pandemic (56%).ConclusionsWe found differences during the COVID-19 pandemic in prioritisation of several ethical factors in the context of ECMO allocation. The ethical principles prioritised by survey participants were largely consistent with ECMO allocation guidelines, current ethical decision procedures and recommendations for allocation of life-sustaining treatment during the COVID-19 pandemic. (shrink)

Planctomycetes, Verrucomicrobia and Chlamydia are prokaryotic phyla, sometimes grouped together as the PVC superphylum of eubacteria. Some PVC species possess interesting attributes, in particular, internal membranes that superficially resemble eukaryotic endomembranes. Some biologists now claim that PVC bacteria are nucleus‐bearing prokaryotes and are considered evolutionary intermediates in the transition from prokaryote to eukaryote. PVC prokaryotes do not possess a nucleus and are not intermediates in the prokaryote‐to‐eukaryote transition. Here we summarise the evidence that shows why all of the PVC traits (...) that are currently cited as evidence for aspiring eukaryoticity are either analogous (the result of convergent evolution), not homologous, to eukaryotic traits; or else they are the result of horizontal gene transfers. (shrink)

Neoplatonic Exegeses of Plato's Cosmogony JOHN F. PHILLIPS AMONG THE MANY CONTROVERSIES to which the long history of interpretation of Plato's Timaeus has given rise, that concerning the eternity of the cosmos is one of the most enduring and complex, and the source of almost continuous debate from the time of Xenocrates to the present. The importance to all Platonists of a doctrinally consistent answer to the question of whether or not the universe had a beginning in time is (...) made amply clear in the statement attributed to Iamblichus by Proclus that proper understand- ing of the creation of the world is crucial for the entire theory of Nature. Iamblichus here refers obliquely to the orthodox Platonist position that the universe is not a temporal being subject to decay and destruction. The princi- pal problem for all of them, of course, was that, taken literally, Plato's account of the creation in the Timaeus, particularly the passage 27C-a8C, appears to be an unequivocal affirmation of a temporal beginning to the cosmos. Espe- cially troublesome was Plato's use of the verb y~yovev in Timaeus 28b 7, which seems to be an explicit claim for an &QX1] in time. That this passage did indeed refer to a temporal beginning was a point that was made repeatedly and forcefully by the chief opponents of the Platonists on this issue, the Peripa- tetics, who, following Aristotle, read the Timaeus creation account literally.' To.. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:NOTES AND DISCUSSIONS 95 OCKHAM ON INTUITIVE COGNITION t In the first part of what follows, I try to locate Ockham's theory of intuitive cognition in the context of one set of philosophical problems rather than another. The device I use is to emphasize the major error Ockham wants to avoid: "platonism" rather than scepticism. In the second part, I try to show how difficulties raised by some recent (...) commentary result from the wrong orientation. This very limited project involves neither exposition nor assessment of Ockham's proposed solutions for the philosophical problems. But hopefully it will prove useful or at least suggestive for others working in this or related areas in Ockham. According to Ockham, 2 someone can be said to hold to or cognize a proposition evidently when he knows it to be true. The paradigm of knowing something to be true is seeing that it follows from the premisses in a demonstrative syllogism. However, first principles, or any proposition per se nota, can also be known to be true or cognized evidently. And, what is most important for our purposes, contingent propositions can be cognized evidently when, as one might say, they are known in experience. When someone is looking at a white wall, to ~se one of Ockham's examples, he can cognize evidently the proposition "The wall is white." 3 i Aside from a few quotations, I have given only the location of references in Ockham. Only very extensive quotations would make the article self-sufficient or, for that matter, even be helpful to the reader. My effort is both tentative and parasitic on earlier commentary and can, perhaps, be excused from providing logistic support that would far exceed its own weight. Moreover, I have tried to direct the reader to the most convenient materials, using fairly common or obvious abbreviations for Ockham's writings and the symbols given in the brackets for each of these sources. [Baudry] L Baudry, Lexique philosophique de Guillaume d'Ockham (Paris, 1958). [McKeon] R. McKeon, Selections /tom Medieval Philosophers, Vol. II (New York, 1929). This almost literal translation of selected Quodlibeta is sufficient for my present purposes. The Strasbourg edition of 1491, of course, is not more readily available m the reimpression from Louvain, Editions de la Biblioth~que Sd., 1962. [OPW] P. Boehner, Ockham: Philosophical Writings (New York, 1957). The page numbers given are from the Nelson edition, containing both Latin and English. The Library of Liberal Arts (Bobbs-Merrill) edition which consists only of the English text runs from one to sixteen pages ahead as a result of numbering the blank pages at the beginning of each section. [Ordinatio] Opera Philosophica et Theologica (St. Bonaventure, N.Y., 1967). Vol. I: Scripture in Librum Primum Sententiarum Ordinatio, Prologus et Distinctio Prima, edited by G. Gal and S. Brown. The lines referred to are given as superscripts to the page numbers. a Expos. Physicorum, Prologue ([OPW] pp. 4-5). See also [Baudry] under scire and evidens. a The issue of translation raises a host of problems of varying degrees of philosophical importance. I am not settled in my own mind about the best English equivalents for many important terms, and in my translations and commentary I have not tried for consistency. In principle, I prefer odd or quaint terms, since they bear their faults on their 96 HISTORY OF PHILOSOPHY At one point, Ockham gives this description: Whoever knows some proposition evidently cannot dissent from that proposition by the power of the will alone, but it is necessary that he be persuaded by an argument more strongly moving his intellect to dissent, or it is necessary that he have forgotten something evidently known.4 Let me call your attention to the un-Cartesian way in which Ockham removes the judgement of some contingent (and all necessary) propositions from the (total) dominion of the will. I may remain silent or talk of something else, or I may avail myself of questions and conditionals, but if I intend to deal head-on with equals added to equals or (while looking at the white wall) with walls and whiteness, I cannot but assert that equals added to equals are equal or... (shrink)

Blindsight is the term commonly used to describe visually guided behaviour elicited by a stimulus falling within the scotoma (blind area) caused by a lesion of the striate cortex. Such is normally held to be unconscious and to be mediated by subcortical pathways involving the superior colliculus. Blindsight is of considerable theoretical importance since it suggests that destriate man is more like destriate monkey than had been previously believed and also because it supports the classical notion of two visual systems. (...) It is also of potential clinical importance, since it has been claimed recently that systematic practice in blindsight can lead to the recovery of normal visual function in patients with cortical lesions. From a review of the literature it is concluded that all of the phenomena of blindsight can be attributed either to light scatter into unimpaired parts of the visual field or to residual vision resulting from spared striate cortex. The possible contribution f other factors is also considered. It is concluded that blindsight studies have generally failed to control for such nonblindsight interpretations partly because of poor methodology and partly because of difficulties in defining the term. (shrink)

There are two popular views regarding the origin of critical thinking: (1) The concept of critical thinking began with Socrates and his Socratic method of questioning. (2) The term ‘critical thinking’ was first introduced by John Dewey in 1910 in his book How We Think. This paper argues that both claims are incorrect. Firstly, critical reflection was a distinguishing characteristic of the Presocratic philosophers, setting them apart from earlier traditions. Therefore, they should be recognized as even earlier pioneers of (...) critical thinking. Secondly, John Dewey not only used the term ‘critical thinking’ before 1910, but there were also other authors who used it before him. The meaning of ‘critical thinking’ at the turn of the twentieth century was shaped by various traditions of linguistic usage, including literary criticism, science and medicine, and Kantian philosophy. (shrink)

La enseñanza moral católica afirma que es necesario el consentimiento de los pacientes para autorizar las intervenciones sanitariasque les afectan, pero no especifica las condiciones para obtener dicho consentimiento o evaluar la capacidad de decisión. Aquí se presentan los artículos recogidos en este número que los autores han desarrollado a partir de las presentaciones que hicieron durante un coloquio reciente de la Asociación Internacional de Bioética Católica (IACB) celebrado en Quebec, Canadá. Contribuyen a promover el pensamiento ético sobre la capacidad (...) de toma dedecisiones y el consentimiento. De diversas formas, piden que se respete la dignidad de todos los pacientes y que se promueva su participación tanto como sea posible en la toma de decisiones sobre su salud. Consideran que la toma de decisiones es relacional y abarca una variedad de capacidades. Examinan el papel de los miembros de la familia y de otros partidarios de la toma de decisiones en la promoción de las capacidades de los pacientes, cuya condición de salud mental o discapacidad les impide a menudo cumplir con los estándares clínicos y legales típicos para la capacidad de toma de decisiones. (shrink)

Whiskey Lao -- Fair warning -- Randomness at large -- We the addicted -- The best possible world -- The importance of being doomed -- Moral responsibility -- The upper limit to the value of possible worlds.

sn y™to˜er —nd xovem˜er IWHUD just over two ye—rs —fter the ™ompletion of his spe™i—l theory of rel—tivityD iinstein m—de the ˜re—kthrough th—t set him on the p—th to the gener—l theory of rel—tivityF ‡hile prep—ring — review —rti™le on his new spe™i—l theory of rel—tivityD he ˜e™—me ™onvin™ed th—t the key to the extension of the prin™iple of rel—tivity to —™™eler—ted motion l—y in the rem—rk—˜le —nd unexpl—ined empiri™—l ™oin™iden™e of the equ—lity of inerti—l —nd gr—vit—tion—l m—ssesF „o interpret (...) —nd exploit this ™oin™iden™eD he introdu™ed — new —nd powerful physi™—l prin™ipleD soon to ˜e ™—lled the ’prin™iple of equiv—len™e4 upon whi™h his se—r™h for — gener—l theory of reE l—tivity would ˜e ˜—sedF woreoverD with the ™ompletion of the theory —nd throughout the rem—inder of his lifeD iinstein insisted on the fund—ment—l import—n™e of the prin™iple to his gener—l theory of rel—tivityF iinstein9s insisten™e on this point h—s ™re—ted — puzzle for philosophers —nd histori—ns of s™ien™eF st h—s ˜een —rgued vigorously th—t the prin™iple in its tr—dition—l formul—tion does not hold in th™ gener—l theory of rel—tivityD gonsiderD for ex—mpleD — tr—dition—l formul—tion su™h —s €—uli9s in his IWPI Encyklopadie —rti™leF por €—uli the prin™iple —sserts th—t one ™—n —lw—ys tr—nsform —w—y —n —r˜itr—ry gr—vit—tion—l eld in —n innitely sm—ll region of sp—™eEtimeD ˜y tr—nsforming to —n —ppropri—te ™oordin—te system @€—uli IWPID pF IRSAF sn responseD su™h eminent rel—tivists —s ƒynge @IWTHD pF ixAD —nd even iddington ˜efore him @IWPRD ppF QW{RIAD h—ve o˜je™ted th—t — ™oordin—te tr—nsform—tion or ™h—nge of st—te of motion of the o˜server ™—n h—ve no ee™t on the presen™e or —˜sen™e of — gr—vit—tion—l eldF „he presen™e of — ’true4 gr—vit—tion—l eld is determined ˜y —n inv—ri—nt ™riterionD the ™urv—ture of the metri™F „he gr—vit—tionEfree ™—se of spe™i—l rel—tivity is just the ™—se in whi™h this ™urv—ture v—nishesD where—s the true gr—vit—tion—l elds of gener—l rel—tivity —re distinguished ˜y the nonv—nishing of this ™urv—tureF „his o˜je™tion h—s immedi—te r—mi™—tions for the ’iinstein elev—tor4 thought experimentD whi™h is ™ommonly used in the formul—tion of the prinE ™iple of equiv—len™eF sn this thought experimentD — sm—ll ™h—m˜ers su™h —s.... (shrink)

En esta nota, estudiaremos el último libro de Foster y McChesney. Primero, consideraremos la tesis principal del grupo de la Monthly Review: el estancamiento crónico en el capitalismo monopolista. En segundo lugar, examinaremos el concepto de capitalismo monopolistafinanciero de Foster. Para terminar, veremos si el argumento sobre la crisis interminable es acertado, o esta crisis puede conducir a nuevas instituciones dentro del sistema, asegurando la acumulación de capital.

Chapin reviewed this 1972 ZEITSCHRIFT paper that proves the completeness theorem for the logic of variable-binding-term operators created by Corcoran and his student John Herring in the 1971 LOGIQUE ET ANALYSE paper in which the theorem was conjectured. This leveraging proof extends completeness of ordinary first-order logic to the extension with vbtos. Newton da Costa independently proved the same theorem about the same time using a Henkin-type proof. This 1972 paper builds on the 1971 “Notes on a Semantic Analysis (...) of Variable Binding Term Operators” (Co-author John Herring), Logique et Analyse 55, 646–57. MR0307874 (46 #6989). A variable binding term operator (vbto) is a non-logical constant, say v, which combines with a variable y and a formula F containing y free to form a term (vy:F) whose free variables are exact ly those of F, excluding y. Kalish-Montague 1964 proposed using vbtos to formalize definite descriptions “the x: x+x=2”, set abstracts {x: F}, minimization in recursive function theory “the least x: x+x>2”, etc. However, they gave no semantics for vbtos. Hatcher 1968 gave a semantics but one that has flaws described in the 1971 paper and admitted by Hatcher. In 1971 we give a correct semantic analysis of vbtos. We also give axioms for using them in deductions. And we conjecture strong completeness for the deductions with respect to the semantics. The conjecture, proved in this paper with Hatcher’s help, was proved independently about the same time by Newton da Costa. (shrink)

In this volume, John Horty brings to bear his work in logic to present a framework that allows for answers to key questions about reasons and reasoning, namely: What are reasons, and how do they support actions or conclusions?

This article extends earlier research concerning the relationship between corporate social performance and corporate financial performance, with particular emphasis on methodological inconsistencies. Research in this area is extended in three critical areas. First, it focuses on a particular industry, the chemical industry. Second, it uses multiple sources of data-two that are perceptual based (KLD Index and Fortune reputation survey), and two that are performance based (TRI database and corporate philanthropy) in order to triangulate toward assessing corporate social performance. Third, it (...) uses the five most commonly applied accounting measures in the corporate social performance and corporate financial performance (CSP/CFP) literature to assess corporate financial performance. The results indicate that the a priori use of measures may actually predetermine the CSP/CFP relationship outcome. Surprisingly, Fortune and KLD indices very closely track one another, whereas TRI and corporate philanthropy differentiate between high and low social performers and do not correlate to the firm's financial performance. (shrink)

Peter Abelard (1079–1142 ce) was the most wide‐ranging philosopher of the twelfth century. He quickly established himself as a leading teacher of logic in and near Paris shortly after 1100. After his affair with Heloise, and his subsequent castration, Abelard became a monk, but he returned to teaching in the Paris schools until 1140, when his work was condemned by a Church Council at Sens. His logical writings were based around discussion of the “Old Logic”: Porphyry's Isagoge, aristotle'S Categories and (...) On Interpretation and boethius'S textbook on topical inference. They comprise a freestanding Dialectica (“Logic”; probably c.1116), a set of commentaries (known as the Logica [Ingredientibus], c. 1119) and a later (c. 1125) commentary on the Isagoge (Logica Nostrorum Petititoni Sociorum or Glossulae). In a work Abelard called his Theologia, issued in three main versions (between 1120 and c.1134), he attempted a logical analysis of trinitarian relations and explored the philosophical problems surrounding God's claims to omnipotence and omniscience. The Collationes (“Debates,” also known as “Dialogue between a Christian, a Philosopher and a Jew”; probably c.1130) present a rational investigation into the nature of the highest good, in which the Christian and the Philosopher (who seems to be modeled on a philosopher of pagan antiquity) are remarkably in agreement. The unfinished Scito teipsum (“Know thyself,” also known as the “Ethics”; c.1138) analyses moral action. (shrink)

IN 1903, commenting on an article he had written more than thirty years before, Charles Peirce said that he had changed his mind on many issues at least a half-dozen times but had "never been able to think differently on that question of nominalism and realism" (1.20). For anyone acquainted with Peirce's writings, this remark alone could justify a study of "that question.".

Originally published in 1830, this book can be called the first modern work in the philosophy of science, covering an extraordinary range of philosophical, methodological, and scientific subjects. "Herschel's book . . . brilliantly analyzes both the history and nature of science."—Keith Stewart Thomson, American Scientist.

Written by a highly respected scholar of Thomas Aquinas's writings, this volume offers a comprehensive presentation of Aquinas's metaphysical thought. It is based on a thorough examination of his texts organized according to the philosophical order as he himself describes it rather than according to the theological order. -/- In the introduction and opening chapter, John F. Wippel examines Aquinas's view on the nature of metaphysics as a philosophical science and the relationship of its subject to divine being. Part (...) One is devoted to his metaphysical analysis of finite being. It considers his views on the problem of the One and the Many in the order of being, and includes his debt to Parmenides in formulating this problem and his application of analogy to finite being. Subsequent chapters are devoted to participation in being, the composition of essence and esse in finite beings, and his appeal to a kind of relative nonbeing in resolving the problem of the One and the Many. Part Two concentrates on Aquinas's views on the essential structure of finite being, and treats substance-accident composition and related issues, including, among others, the relationship between the soul and its powers and unicity of substantial form. It then considers his understanding of matter-form composition of corporeal beings and their individuation. Part Three explores Aquinas's philosophical discussion of divine being, his denial that God's existence is self-evident, and his presentation of arguments for the existence of God, first in earlier writings and then in the "Five Ways" of his Summa theologiae. A separate chapter is devoted to his views on quidditative and analogical knowledge of God. The concluding chapter revisits certain issues concerning finite being under the assumption that God's existence has now been established. -/- John F. Wippel, professor of philosophy at The Catholic University of America, was recently awarded the prestigious Aquinas Medal by the American Catholic Philosophical Association. In addition to numerous articles and papers, Wippel has coauthored or edited several other works, including Metaphysical Themes in Thomas Aquinas and The Metaphysical Thought of Godfrey of Fontaines, both published by CUA Press. (shrink)

John F. Post argues that physicalistic materialism is compatible with a number of views often deemed incompatible with it, such as the objectivity of values, the irreducibility of subjective experience, the power of the metaphor, the normativity of meaning, and even theism.

inheritance reasoning in semantic networks allowing for multiple inheritance with exceptions. The approach leads to a definition of iaheritance that is..

This paper describes one way in which a precise reason model of precedent could be developed, based on the general idea that courts are constrained to reach a decision that is consistent with the assessment of the balance of reasons made in relevant earlier decisions. The account provided here has the additional advantage of showing how this reason model can be reconciled with the traditional idea that precedential constraint involves rules, as long as these rules are taken to be defeasible. (...) The account presented is firmly based on a body of work that has emerged in AI and Law. This work is discussed, and there is a particular discussion of approaches based on theory construction, and how that work relates to the model described in this paper. (shrink)

The multistep pathway of eukaryotic gene expression involves a series of highly regulated events in the nucleus and cytoplasm. In the nucleus, genes are transcribed into pre‐messenger RNAs which undergo a series of nuclear processing steps. Mature mRNAs are then transported to the cytoplasm, where they are translated into protein and degraded at a rate dictated by transcript‐ and cell‐type‐specific cues. Until recently, these individual nuclear and cytoplasmic events were thought to be primarily regulated by different RNA‐ and DNA‐binding proteins (...) that are localized either only in the nucleus or only the cytoplasm. Here, we describe multifunctional proteins that control both nuclear and cytoplasmic steps of gene expression. One such class of multifunctional proteins (e.g., Bicoid and Y‐box proteins) regulates both transcription and translation whereas another class (e.g., Sex‐lethal) regulates both nuclear RNA processing and translation. Other events controlled by multifunctional proteins include assembly of spliceosome components, spliceosome recycling, RNA editing, cytoplasmic mRNA localization, and cytoplasmic RNA stability. The existence of multifunctional proteins may explain the paradoxical involvement of the nucleus in an RNA surveillance pathway (nonsense‐mediated decay) that detects cytoplasmic signals (premature termination codons). We speculate that shuttling multifunctional proteins serve to efficiently link RNA metabolism in the cytoplasmic and nuclear compartments. BioEssays 23:775–787, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

An acceptable empiricist account of laws of nature would havesignificant implications for a number of philosophical projects. For example, such an account may vitiate argumentsthat the fundamental constants of nature are divinelydesigned so that laws produce a life permittinguniverse. On an empiricist account, laws do not produce the universe but are designed by us to systematize theevents of a universe which does in fact contain life; so any ``fine tuning'' of natural law has a naturalistic explanation.But there are problems for (...) the empiricist project. This paper develops a ``perspectival'' version of the Humean bestsystem approach and argues that this version solves the standard problems faced by the empiricist project.Furthermore, the paper argues, this version is best able to answer the proponents of divine design while leaving scientificlaw a suitably objective matter.[I]t is possible tocondense the enormous mass of results to a large extent – that is to find laws which summarize...Richard Feynman It has become fashionable in some circles to argue thatscience is ultimately a sham, that we scientists read order into nature, not out of nature, and that the laws of physicsare our laws, not nature's. I believe this is arrant nonsense. You would be hard-pressed to convince a physicist thatNewton's inverse square law of gravitation is a purely cultural concoction. The laws of physics, I submit, reallyexist in the world out there, and the job of the scientist is to uncover them, not invent them. True, at any giventime, the laws you find in the textbooks are tentative and approximate, but they mirror, albeit imperfectly, a reallyexisting order in the physical world. Of course, many scientists do not recognize that in accepting the reality of anorder in nature-the existence of laws `out there' – they are adopting a theological world view. P. C. W. Davies. (shrink)

This paper develops a pragmatist approach to ethical business decision-making. It draws primarily on the work of John Dewey and applies his deliberative approach to ethics to the challenges of business practitioners. In particular the paper proposes the value of Dewey’s concept of dramatic rehearsal in emphasizing the task of “constructing the good” in ethical decision-making. The contribution of the paper is, first, to build on recent foundational work to bring American pragmatism into the mainstream business ethics literature; second, (...) to offer a perspective that is accessible to practitioners and integrates ethics into their daily tasks; and third, to identify a number of related research imperatives – in particular the importance of focusing efforts on gaining a deeper understanding of the deliberative process itself. (shrink)

Bentham enunció el principio de utilidad por primera vez en el Fragmento sobre el Gobierno, que apareció en 1776. No se sabe con exactitud el proceso intelectual por el que atravesó Bentham antes de llegar a enunciarlo. En ninguna de las cartas que escribió entre 1768 y 1769 existe la menor referencia al descubrimiento, lo que habría sido razonable suponer, si tenemos en cuenta la extraordinaria importancia que el principio tuvo para el desarrollo de su filosofía moral y los programas (...) de reformas sociales y de legislación con los que estuvo comprometido el resto de su vida. La evidencia sobre el hallazgo y enunciación del principio del principio hay que buscarla en lo que, ya casi al final de su vida, le comunicó personalmente a John Bowring. (shrink)

The reason for physics’ failure to find a final theory of the universe is examined. Problems identified are: the lack of unequivocal definitions for its fundamental elements (time, length, mass, electric charge, energy, work, matter-waves); the danger of relying too much on mathematics for solutions; especially as philosophical arguments conclude the universe cannot have a mathematical basis. It does not even need the concept of number to exist. Numbers and mathematics are human inventions arising from the human predilection for measurement. (...) Following Aristotle, a single fundamental cause is proposed to explore the efficacy of using pure non-mathematical philosophy to explain the universe, contrary to current quantum physical views. The cause is taken as Time, which is then defined, surprisingly leading automatically to a definition of a three-dimensional space answering the question into what can a universe be placed (space before space seems non-sensical). This enables the philosophical arguments to derive a universal rule giving clear-cut descriptions (definitions) of force (both gravitational and electromagnetic), motion, energy, and particles. The formation of atomic nuclei and atomic properties together with an unexpected role for neutrinos follow. In particular, a Popper-test can be prepared by introducing the concept of measurement to allow the philosophy arguments to be tested in another discipline - mathematics. The solution agrees with human physical observations to a remarkable degree of accuracy, automatically explaining and predicting values for Planck’s and the fine-structure constants. Although mathematical, it is included as confirming the efficacy of philosophy in attaining a final theory. (shrink)

Let us say that a normative conflict is a situation in which an agent ought to perform an action A, and also ought to perform an action B, but in which it is impossible for the agent to perform both A and B. Not all normative conflicts are moral conflicts, of course. It may be that the agent ought to perform the action A for reasons of personal generosity, but ought to perform the action B for reasons of prudence: perhaps (...) A involves buying a lavish gift for a friend, while B involves depositing a certain amount of money in the bank. In general, our practical deliberation is shaped by a concern with a variety of morally neutral goods—not just generosity and prudence, but any number of others, such as etiquette, aesthetics, fun—many of which are capable of providing conflicting reasons for action. I mention these ancillary values in the present setting, however, only to put them aside. We will be concerned here, not with normative conflicts more generally, but precisely with moral conflicts—situations in which, even when our attention is restricted entirely to moral reasons for action, it is nevertheless true that an agent ought to do A and ought to do B, where it is impossible to do both. (shrink)